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Omega 3 Natural Fish Oil Squalene - Deep Sea Shark Liver Oil Extract
Introduction History & Discovery Sources and Properties Occurrence in Humans Cholesterol Metabolism Cancer Antioxidant Coronary Heart Diseases Skin Care Toxicity & Dosage References
 
Bullet

Cancer


Olive oil is the staple source of dietary fat among people of Greece and many European countries. Epidemiological studies in the latter part of the 20th century showed that people who eat the so called Mediterranean diets have lower incidence of major disease like cancer and cardiovascular diseases. Consumption of olives and olive oil containing squalene is found to be responsible for these beneficial effects.


Olive oil is the staple source of dietary fat among people of Greece and many European countries. Epidemiological studies in the latter part of the 20th century showed that people who eat the so called Mediterranean diets (Gjonca & Bobak, 1997; Buckland et al., 2011) have lower incidence of major disease like cancer and cardiovascular diseases. Consumption of olives and olive oil containing squalene is found to be responsible for these beneficial effects.

Those women who consume large quantities of olive oil have lesser risk of breast cancer (Kelly, 1999; Newmark, 1997; Owen et al., 2004). It is now well established that olive oil contains squalene and the beneficial effect of resistance to cancer may be due to the squalene present in olive oil.



Those women who consume large quantities of olive oil have lesser risk of breast cancer
Squalene is now being used as a prophylactic agent after irradiation treatment of cancer patients.


The studies conducted on animals also support this observation of decreased incidence of breast cancer (Kate et al., 1992). Animal studies have shown that squalene is effective in inhibiting lung tumors. Squalene is also found to have chemo-preventive action against colon cancer and enhanced immune function (Nakagawa et al., 1985; Ikikawa et al., 1986; Rao et al., 1998). Hence, squalene is now being used as a prophylactic agent after irradiation treatment of cancer patients.

Squalene carries oxygen to cells (Strandberg, 1990; Wefers et al., 1991) and thereby enhances the function of several organs like liver and kidney (Kelly, 1999). It also prevents acidotic cell syndrome disease in which the cells become acidic and die due to absence of oxygen. Squalene is an excellent scavenger of free radicals and thereby protects cells and organs from auto-oxidative damages.

Squalene carries oxygen to cells and thereby enhances the function of several organs like liver and kidney
Squalene It also prevents acidotic cell syndrome disease in which the cells become acidic and die due to absence of oxygen.

Animal studies in recent times have shown that squalene in sebum played a protective role against formation of hydrocarbon carcinogens in skin and prevented damages caused by radiation therapy (Wefers et al., 1991; Strandberg, 1990). Being a natural product used by man from time immemorial, its consumption is harmless and has no side effects.

One of the major limitations of cancer chemotherapy is the indiscriminative injury of normal tissues, leading to multiple organ toxicity and consequent dose limitation/treatment failure (Das et al., 2003). The resultant problems are myelo-suppression, renal toxicity and neuropathy having profound effects on adults and children with long term remission that affects not only therapy but also overall quality of life (Bukowski, 1999). Often, free radicals produced by chemicals and radiation therapy are the major problems. Scavenging these free radicals is important to minimize the toxicity of chemotherapy. Antioxidants are extensively used for this purpose.

Several experimental studies conducted using squalene had demonstrated that it is an excellent detoxifying agent against toxic and carcinogenic chemicals like hexachlrobiphenyl, hexachlorobenzene, arsenic, theophilline, phenobarbital and strychnine (Kamimura et al., 1992; Richter & Schafer, 1982; Fan et al., 1996). Squalene has also been reported to have protective activity against nicotine-derived nitrosamineketone (NMK) -induced lung cancer (Smith et al., 1998).


Squalene is an excellent scavenger of free radicals and thereby protects cells and organs from auto-oxidative damages.
Being a natural product used by man from time immemorial, its consumption is harmless and has no side effects.

Most antioxidants used today have side effects and thus fail to get approval from certifying agencies like the USFDA or WHO. Hence, there is an urgent need to develop new generation of antioxidants having essential characteristics like better safety profile, good oral availability and meeting basic qualities required for a cytoprotective agent (Das et al., 2003). Squalene being a naturally occurring cytoprotective agent, toxicity of this compound has not been reported so far.




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