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Omega 3 Natural Fish Oil Squalene - Deep Sea Shark Liver Oil Extract
Introduction History & Discovery Sources and Properties Occurrence in Humans Cholesterol Metabolism Cancer Antioxidant Coronary Heart Diseases Skin Care Toxicity & Dosage References
 
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Coronary Heart Diseases


The widespread occurrence of coronary heart disease is chiefly attributed to modern life style and food habits.



Dietary squalene has been found to lower cholesterol levels in blood and also to reduce LDL and to increase HDL

Dietary squalene has been found to lower cholesterol levels in blood and also to reduce LDL and to increase HDL (Ikikawa et al., 1986). This effect is due to efficiency of squalene to down-regulate the HMGCoA reductase which in turn enhances the capacity of liver to filter bad cholesterol.

These findings are supported by epidemiological correlation studies of squalene rich olive oil consuming population having low incidence of CHD.

The cholesterol lowering property of squalene has prompted pharmacologists to combine squalene with statin drugs (used to lower cholesterol levels) and to use in human therapeutic applications. This leads to lower doses of drug formulations and reduction in potential side effects of statins. This can also reduce in the long term, therapeutic costs of patients having hypercholesterolemia.

The cholesterol lowering property of squalene has prompted pharmacologists to combine squalene with statin drugs (used to lower cholesterol levels) which lowers the doses of drug formulations and reduction in potential side effects of statins.


A clinical trial conducted by Chan et al. (1996) showed the effectiveness and safety of squalene alone and in combination with pravastatin in lowering the cholesterol levels. This double blind placebo-controlled, 20-week trial was conducted on a randomized selection of 102 elderly people, all suffering from high cholesterol levels. They received 10 mg pravastatin and/or 860 mg squalene daily either separately or in combination. The results showed that both pravastatin and squalene effectively reduced levels of total cholesterol and LDL cholesterol and increased levels of HDL cholesterol.

The study concluded that

(i)      co-administration of pravastatin and squalene combined the effects of the two
          drugs on lipoprotein concentrations;
(ii)      The combination may be useful and cost-effective in elderly patients with           hypercholesterolemia, who might have a higher incidence of side effects when
          using larger doses of pravastatin alone. Farvin et al. (2009b) reported the
          cardioprotective effect of squalene against isoprenaline-induced myocardial
          infarction in rats.



Although squalene is an intermediate in the cholesterol biosynthesis in animals, intake of squalene by man has not shown increase in serum cholesterol levels. On the contrary, squalene is seen to reduce cholesterol levels in man. This makes it safe for human consumption. In Greece and Italy, average intake of squalene is 200-400 mg day-1 while in United States, the consumption is only 30 mg day-1 (Yokota, 1997).




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