What is Green Lipped Mussel Extract (GLME)?
The green lipped mussel is a shellfish that’s native to New Zealand (Perna canaliculus). Its name comes from the green lip around the edge of its shell. The green lipped mussel is one of the largest mussel species in existence, and can grow up to 240 mm in length.
The green lipped mussels are grown in dedicated farms in the pristine waters of New Zealand, usually in sheltered waters close to the shore. The mussel industry operates within some of the stringent quality standards in the world. Both the mussels and seawater around the farms are tested for Biotoxins, bacteria, and heavy metals. In addition, the water quality is constantly monitored with tests carried out to the standards set by the U.S Food and Drug Administration, European Union, and NZ Food Safety Authority.
New Zealand’s indigenous Maori people have claimed for centuries that consuming green lipped mussels has helped them maintain good health.
GLME or Green Lipped Mussel Extract performs two distinct anti-inflammatory activities.
The principal anti-inflammatory activity is due to a carbohydrate complex that has the ability to inhibit the emigration of neutrophils from the blood vessels. What this means, in everyday terms, is that soldier cells (neutrophils) are inhibited from attacking our own cells when an inflammatory stimulus is present. Preventing inflammation with its associated pain and reduced mobility symptoms is a primary requirement for an arthritis treatment.
Another valuable feature of the product is that it has been found to have natural gastro-protective properties. This means that, not only does it not damage the delicate stomach lining; it actually provides a protective function for it. Thus the product is able to relieve the inflammatory symptoms associated with arthritic diseases whilst protecting the stomach from the damaging effect of some pain-killers should a person need to be taking these at the same time.
What is the significance and effect of Green Lipped Mussel Extract (GLME) for bone and joint health?
GLME is a potent marine product that contains the components that the body requires to effectively relieve the symptoms of arthritis without inducing the classical adverse effects associated with many drug therapies. It is a reliable dietary supplement that works without causing any unpleasant effects. Even it has natural gastro-protective properties. It protects the delicate stomach lining. Thus the product is able to relieve the inflammatory symptoms associated with arthritic diseases whilst protecting the stomach from the damaging effect of some pain-killers should a person need to be taking these at the same time.
Following are the major benefits of GLME:
- It improves the joint lubrication and therefore it increases the mobility of joints that are affected by the arthritis.
- Cartilage is the slippery tissue which coats the ends of bones joint is formed. It prevents the cartilage decline and aids the repair of damaged cartilage. Therefore it is known to carry chondro protective actions.
- It has gastro-protective actions. Therefore it protects stomach lining from the harsh medications that damage the delicate stomach lining of stomach used during the painful conditions of arthritis.
- It has great anti-inflammatory actions. Therefore it decreases the pain, inflammation, and stiffness through different mechanisms.
How GLME is Better than Traditional Medicines?
The GLME is natural product with multi compounds. It has chondro-protective, gastro-protective and anti-inflammatory actions. It is effective in both osteoarthritis and rheumatoid arthritis. It has long-chain fatty acids and a wide range of therapeutic polysaccharides. Its higher doses will never show adverse effects. It produces the long lasting effects. A great care and wide safety measures are taken to acquire a higher quality of this product. Starting from the raw material till the extraction a great effort is done to avoid contamination with Biotoxins, microorganisms, pesticides and heavy metal contaminants. The GLM of licensed marine farms is used for extraction. Therefore the GLM extracts which are available to you are of highest international standards. While the traditional medicines or the herbal medicines available do not meet such standards of processing. Even the raw material in traditional medicines is not checked for the contamination. The medicinal parts of herbal medicines are generally not checked for the percentage of the active ingredients and components. Therefore there is great risk of side effects by using these medicines. Moreover it may take a long time to get relieved by using these medicines and there action may only be temporary.
The therapeutic effect results from the complementary effects of the unique combination of biologically active compounds found in the green-lipped mussel as follows:
Glycosaminoglycans (GAG) Synthesis
GLM Extract contains Glucosamine, Chondroitin sulphate, Hyaluronic acid and Dermantan Sulphate. GLM Extract is a natural source of glucosamine – not free glucosamine – a component of joint cartilage and of synovial fluid that has been shown to slow the structural damage within arthritic joints. Chondroitin sulphate makes up the basic ground substance of both, the bone and cartilage and may inhibit catabolic cytokine initiated degradation of the cartilage. Hyaluronic acid is a nonsulphated GAG found in the proteoglycans structure and it also contributes to the viscosity of the synovial fluid.
Inhibition of Cytokine Function
Cytokines are chemical messengers produced by cells in response to a variety of stimuli. Catabolic cytokines present in arthritic joints perform a number of detrimental functions, which result in an accelerated breakdown of cartilage and enhanced inflammation. The catabolic cytokines, Interleukin-1 (IL-1), Interleukin-2 (IL-2) and Tumor Necrosis Factor – alpha (TNF-) are the ones mainly associated with destructive function in the arthritic joint due to their influence on neutrophils infiltration, matrix metalloproteinase and proinflammatory prostaglandin production. Studies using arthritic rats have demonstrated the inhibitory effect of GLM Extract on neutrophils activity and pro-inflammatory prostaglandin synthesis along with the inhibition of catabolic cytokine activity at the cellular level.
Selective COX-2 Inhibition
GLM Extract is a selective inhibitor of cyclo-oxygenase type 2. Inhibiting the activity of cycloxygenase enzymes, which convert cell membrane phospholipids into pro-inflammatory prostaglandins, is an important anti-inflammatory mechanism. However, there are two isozyme of cycloxygenase, designated as COX-1 and COX-2. The COX-1 isozyme is a constitutional enzyme that has an important role in maintaining the health and integrity of the digestive system, kidney function and platelet aggregation whereas, COX-2 isozyme is induced in response to an inflammatory stimulus. The fact that GLM Extract is able to inhibit COX-2 selectivity without inhibiting COX-1 activity means that the product does not have any damaging effects on the stomach and does not adversely affect kidney function or platelet aggregation.
In addition to cyclo-oxygenase inhibitory activity, GLM Extract has been shown to inhibit 5-Lipoxygenase activity in stimulated human polymorphonuclear leukocytes in vitro. 5-Lipoxygenase activity is similar to cycloxygenase enzymic activity involving the conversion of endogenous arachidonic acid to proinflammatory and broncho-constrictive leukotrienes. These leukotrienes are adversely indicated in arthritic and asthmatic disorders and inhibition of their function is important for the control of these disorders.
Apoptosis is a term used to describe programmed cell death. This is a normal physiological function but can become uncontrolled in some disease states. In arthritis, an elevated level of apoptosis can occur in the body′s white blood cells (T-lymphocytes). T-lymphocytes have been shown to be important mediators in the tissue destruction seen in rheumatoid arthritis. Animal studies have shown that GLM Extract inhibits the accumulation of T-lymphocytes at inflammatory sites. However, this is still to be proven in the case of human lymphocytes.
Inhibition of Histamine Production
Histamine production is normally associated with allergy reactions. However, it is also a component of the acute phase of inflammation and its control is therefore influential in the symptomatic relief of inflammatory disorders such as arthritis. Japanese researchers discovered that GLM Extract naturally contains an active anti-histamine component in the form of Phospholipid Lysolecithin. Although anti-histamine preparations are not a standard part of treatment of arthritic diseases, their complementary function in inhibiting the acute-mediator driven phase of inflammation is beneficial.
GLM Extract is prepared from marine mussels, which have naturally assimilated micronutrients from their sea environment, in a manner, which retains all the components in a stable and functional state. Some minerals such as boron, manganese and copper have influence as anti-inflammatory agents either directly or synergistically with other mediators. Fat-soluble vitamins such as A, D, E and K are not in excess in GLM Extract and there is no danger of hypervitaminosis or biosynthesis of excess calcium.
- Improves joint lubrication.
- Prevents cartilage deterioration.
- Promotes repair of damaged cartilage.
- Improves mobility and range of motion of the affected joint.
- Gastro-protective i.e. it protects stomach lining.
- It appears to impact on the inflammatory process of arthritis via multiple mechanisms thereby reducing pain, stiffness and inflammation.
How GLME is better than NSAIDs?
NSAIDs (Non-steroidal anti-inflammatory drugs) are the drugs which are commonly used to get relief from pain, reduce fever or reduce inflammation in different conditions including arthritis. Also there are some strong NSAIDs which can improve your condition immediately but they causes severe side effects. It is true that NSAIDs provide rapid action but it is also true that they only provide temporary relief while the GLM provides you long lasting effects even if it′s action is slow. NSAIDs can damage your cartilage, can arouse stomach ulceration, and can cause renal dysfunction or hemorrhage. It may also dilute your blood by influencing the platelets, may increase your blood pressure, can increase the chances of heart attacks, and can stimulate the skin problems.
While the GLM extract aids you to regenerate and recover the cartilage. It is gastro-protective and do not effect adversely on platelets and renal function. It does not aggravate your blood pressure nor does it cause the risk of heart attacks. It may help you to treat the condition of psoriasis.
Therefore you can easily find that NSAIDS can show serious adverse effects while the GLM extract is completely safe.
How GLME is better than Glucosamine?
The GLME is natural product with multi compounds. It has chondro-protective, gastro-protective and anti-inflammatory actions. It is effective in both osteoarthritis and rheumatoid arthritis. It has long-chain fatty acids and a wide range of therapeutic polysaccharides. Its higher doses will never show adverse effects. On the other hand, glucosamine is a single compound product. It has only mild anti-inflammatory activity and provides joint and cartilage protection. It is beneficial in Osteoarthritis only. It contains no long-chain fatty acids and contains only one therapeutic polysaccharide. Its higher doses can cause serious unpleasant effects.
What are the Side Effects of GLME?
GLME does not show any side effects. However taking the GLME in following conditions will worsen your condition and will show unfavorable effects:
- The use of GLME in the conditions of gouty arthritis worse the condition of a patient as it will elevate the levels of uric acid which is the major reason behind the gout.
- The people who ever had suffered hypersensitivity to seafood should never use GLME as this will produce severe side effects.
- The use of GLME along with the medications as blood thinners or monoamine oxidase in inhibitory drugs will show adverse effects.
- GLME should never be used in the gestation or lactation period. It can be harmful for fetus and the nursing baby.
- The use of GLME in children is not approved therefore keep it away from the reach of children.
What Are the Contraindications of Green Lipped Mussel Extract?
- The people who are hypersensitive to the use of seafood should never use the Seatone.
- The excess dosage of Seatone can cause nausea, fluid retention, rash or stomach disturbance.
- People who are recommended by the doctor to use salt-free diet should abstain from the use of Seatone as it contains small amounts of natural sea salt and minerals.
- Gout patients should not use the Seatone.
- This product should not be used by the children and the women who are pregnant or lactating.
- This product should not be administered by the people who are under the therapy of blood thinners or any other medications without the consultation of doctor.
What are the components of GLME?
Green lipped mussel (GLM) is an excellent source of essential nutrients. A great nutritional value of GLME is due to the presence of natural lipids, protein, and mineral content that are due to its marine origin. These nutrients make it highly beneficial for health. GLME also contains the natural omega-3 fatty acids and unique types of sterols. The wide range of minerals that are present in it makes it balanced marine nutritional product. It contains:
- Protein: 40-50%
- Carbohydrates: 5-20%
- Lipids: 6-12%
- Moisture: less than 5%
All these nutrients have unique properties that make it highly beneficial for health. It contains immune modulators, anti-inflammatory agents, and many essential building blocks that are required to rebuild collagen, synovial fluid and proteoglycans present in the joints, tendons and ligaments. The different components present in GLME have different roles as follows:
- Glycosaminoglycans: The glycosaminoglycans present in it aids in the lubrication of joints, absorption of shocks and maintenance of articular cartilage.
- Polysaccharide Glycogen: The Polysaccharide Glycogen present in the GLME inhibits the immune activation at the inflammation sites.
- Poly unsaturated fatty acids: The Poly unsaturated fatty acids known as PUFA′s are the secondary anti-inflammatory agents.
- Phospholipid Lysolecithin: The Phospholipid Lysolecithin has anti-histamine effects that decrease the acute phase inflammatory responses.
- Lipid Fractions: The Lipid Fractions protects your stomach lining from the harsh medications and drugs.
How Glme is Obtained?
To obtain the best quality of GLME specific steps are required because only grounding up frozen and cooked mussel powder minimizes and destroys the effectiveness of the product. Therefore the best GLME is obtained after following steps:
Seatone is unique from other GLME as it is extracted only from the premium, fresh mussels when they are in peak condition only with the intention of producing a therapeutic product for joints.
The Company keeps full control of the practice, to make sure that harvesting is done at the best times of each year. Other companies do not take this much control so they use mussels of food-industry grade. Therefore they harvest the mussels year round rather than harvesting them at their peak condition.
In earlier research it was found that only simply drying and then encapsulating mussels will not produce a reliable product. Moreover the non-active components present in the mussels dilute the activity. Seatone is produced by using following two methods to prevent this issue:
- Cold extraction method: Firstly cold extraction method is followed that removes the fresh mussel out of the shell and rapidly extracts and stabilizes the active component.
- Freeze-drying method: Freeze-drying is done to preserve the product and stabilize it.
The Science Behind Biolane® GLME
Benefits of Biolane® GLME is supported by published double-blind, peer-reviewed clinical trials.
Biolane® GLME is also supported by cellular and animal research that helps explain the different mechanisms of action.
Biolane® GLM Extract covers over 20 Research studies conducted by reputable scientist and medical research institutes around the world.
Over 35 years of research has shown that Biolane® GLME is an effective anti-arthritic agent.
The Research was specifically conducted utilizing Biolane® active GLME. Due to the unique Biolane® manufacturing protocol, This research can only be applied to Biolane® GLM Extract and is not valid for other Green Lipped Mussel ingredients or products.
This section contains short summaries of the research studies that show Biolane® Extract’s effectiveness for joint health. Click here to read.