Squalin
What is Squalin (99% Pure Squalene)?
Permalife Squalin® is the excellent source of 99% pure Squalene, which is extracted from the deep sea sharks. Its prolonged use has been found safe as this natural compound is found in our bodies and also found in nature, mostly in plant sources including amaranth seed, olives, rice bran and wheat germ. It can be consumed at high levels through the diet alone, although supplementation can also help.
Healthy as well as imbalance of our body has its origin on the cellular level. The healthier our cells are, the healthier we are. The source of Squalin is essential substance from the very beginning of life. It can be explained by the presence of high concentration of Squalene in newborn babies, responsible for their soft skin, and such babies need to strengthen the immune system in no time after birth. The body of babies and pre-schoolers show the highest levels of Squalene. This fact explains the energetic behaviour and the vivid eyes of young and healthy children. Another fact is, starting with an age of 25 the Squalene level in our body drops significantly. Therefore it is not surprising that round an age of 30 the sports performances of most humans decline. Squalin being 99% pure Squalene can intercept this lack of energy and improve the power output and help protect us from several health ailments.
Squalin acts as a strong antioxidant that helps our cells to avoid oxidative stress and prevents lipid peroxidation. It acts as an immune booster and has the ability to protect cellular structures and improve cellular repair response. It has a crucial role in the moisture regulation of the skin and transportation of the oxygen to and from the skin. It also has positive effects in the management of dermatitis and skin cancer. It regulates the rate of synthesis of HMG Co-A reductase enzyme. It also shows anticancer and cholesterol-lowering benefits.
Dosage & Expectations
Adults and children over 12 years: 1-2 capsules daily or as required.
Children under 12 years: 1 capsule daily.
People who experience fish allergies may avoid taking Squalin.
Safety of Squalene
Squalene supplements have been widely tested for toxicity and there is considerable proof that Squalene is non-toxic. However, not all the Squalene dietary supplements on the market are safe. Some have been found to contain PCBs, heavy metals and other carcinogens. Many of the so-called Squalene supplements offered on the market are actually raw shark liver oil. They have considerably lower levels of Squalene content. It is very important to take only 100% pure and natural extracted Squalene that is standardized and certified. Squalene is safe as long as it is carefully extracted through highly specialized distillation processes and a purity of 99.9% is maintained at every stage of production. The end product should contain not less than 99% Squalene.
Health Benefits of Squalene
Ageing is the natural process of becoming older. However premature aging takes place due to various reasons as poor diet, stress, lack of exercise or lack of enough sleep. Several other factors as high pollution, sun, and ultraviolet exposure also play an important role in causing premature aging. Signs of aging can be classified into four main categories:
- wrinkles
- pigmentation heterogeneities
- lack of firmness of cutaneous tissues
- vascular disorders
All these aging signs are distressing especially for women when they appear. They may lose their confidence and feel uncomfortable in society due to their looks. Well, it is hard to control natural aging but we can prevent premature aging caused by exposure to ultraviolet rays, excess pollution, and sun. This can be done by following several preventive measures and using health supplements that can help you to stay young and keep your skin free from signs of aging. Among a number of a preventive measure against aging, use of health supplements is the excellent and easiest one. Nowadays, many health supplements are accessible that can act as anti-aging. Well, one should have to choose the best among them.
Squalene is found to be an excellent anti-aging substance due to its number of effects. It has a number of properties that are beneficial in keeping skin healthy and young. It helps a person to deal with pollution, ultraviolet rays and various health conditions that can cause premature aging. Its antioxidants properties play a vital role in performing all such functions. It is an excellent antioxidant that has no side effects. It is stable to attack free radicals. Increased formation of free radicals results in oxidative stress that causes imbalance and leads to oxidative damage, cell death, tissue damage and disease. Squalene reduces the oxidative stress and protects the skin against lipid peroxidation as a free oxygen scavenger.
Thus we can conclude that use of squalene in our daily life can help us to keep our skin young naturally. Moreover, with the use of squalene, you need not fear about any side effects as it is natural substance. For women, squalene can act as a miracle in keeping their skin without any flaws and aging signs.
Dry skin is a common condition which we all suffer at sometimes may be due to weather or any other reasons as poor diet. Dry skin looks rough and flaky and the risk of wrinkles for dry skin is quite high. Dry skin can result in a damaged barrier function, increasing long-term inflammation and sensitivity. It finally causes biochemical reactions as collagen breakdown. It can be very unpleasant especially for the women, as all women love to have smooth and supple skin.
Therefore it is very important for women to keep their skin moisturized to avoid early ageing and wrinkles by using moisturizing agents. There are a number of substances which are helpful in moisturizing the skin but the most beneficial for your skin is Squalene because it natural and does not carry any side effects along with it.
Squalene is naturally found in skin. Nearly 10% of the skin surface is formed of squalene. It helps to keep skin healthy in many ways. Moisture maintenance is among the major functions of squalene for skin health. It provides a protective layer to the skin which prevents loss of moisture. According to a research, squalene consumption gives protection to the skin. It also keeps skin healthy and prevents wrinkles. The unsaturated fatty acids present in squalene control the moisture of the skin. The skin which is moisturized never suffers dryness, dullness; flaking, scaling, peeling, cracking, and sagging and bagging that can cause premature ageing. Thus, squalene intake can help to keep skin moisturized and supple even in old age.
Oxygen is the great forgotten nutrient. Its deficiency is found to be the cause of nearly all degenerative diseases. Another threat to our cells is free radical, which causes diseases such as cancer, atherosclerosis, arthritis and diabetes. Free radicals are unstable molecules with unpaired electrons. Free radicals are produced constantly inside and outside the cell, and as by-products of energy-releasing oxidation in the mitochondria, others by UV light, radioactivity and the metabolism of drugs and chemicals.
Antioxidants neutralize these free radicals, otherwise increased generation of free radicals can result in oxidative stress, causing imbalance that leads to oxidative damage, cell death, tissue damage and disease.
Some of the benefits of antioxidants for human health are as follows:
- Retards the signs of ageing
- Healthier and young looking skin
- Decreases the risk of cancer
- Supports the detoxification
- Longer life span
- Protects against stroke and heart disease
- Reduces the risk for cognitive problems
- Decreases the risk of vision loss or eye disorders
Squalene is an excellent antioxidant due to its molecular structure. It possesses great capacity to receive or donate electrons without suffering molecular disruption. Squalene’s powerful free radical-quenching ability has been shown to be equal to that of BHT (butylated hydroxytoluene), one of the most powerful antioxidants known to science. This unique stability is the key to Squalene′s ability to terminate the on-going or chain damage inside our bodies (lipid peroxidation chain reaction). According to laboratory research, this happens specifically in the skin’s surface. It is reasonable to assume that it performs a similar function wherever it is found, for example within individual cells and in the biomembrane.
Breast cancer is a cancer, which forms in the cells of the breasts. Breast cancer is the second most common cancer diagnosed in women. Breast cancer can develop in both men and women; however, it is much more common in women. Some of the common symptoms of breast cancer can be breast lump, change in size of the breast, peeling, scaling or crusting of the pigmented area of skin around the nipple, changes in skin over the breast, redness or pitting of the skin over the breast.
Considerable support for breast cancer awareness has helped to create advances in its diagnosis and treatment. The survival rates have increased for breast cancer and the number of deaths linked with this disease is progressively declining because of the factors as detection at an early stage, a better understanding of the diseases and a new modified approach to treatment. Also, the studies were done by the researchers to show the benefits of squalene for breast cancer also helped the people to prevent the development of breast cancer.
Squalene is an excellent scavenger of free radicals; thus it protects cells and organs from auto-oxidative damages. On the other side, most antioxidants have side effects and they fail to get approval from certifying agencies. Hence, it is crucial to use antioxidants which are having essential characteristics as better safety profile and good oral availability. Squalene is among those antioxidants that match these characteristics.
Animal studies done in recent times shown that squalene in sebum play a protective role against the production of hydrocarbon carcinogens in the skin and also prevented the damages caused by radiation therapy. As it is a natural product, its consumption has no side effects, it is harmless. Several experimental studies have shown that the squalene is an excellent detoxifying agent against toxic and carcinogenic chemicals like hexachlorobiphenyl, theophylline, Phenobarbital, hexachlorobenzene, arsenic and strychnine.
It was found that those women who consume large quantities of olive oil have a much lesser risk of developing breast cancer. Therefore squalene is now being used in cancer patients as a prophylactic agent after irradiation treatment. The mechanism behind the function of squalene as prophylactics agent for cancer is its ability to reduce mutated ras oncogene activation. Ras oncogene is a family of genes which make proteins associated with cell signalling pathways that manage cell growth and cell death.
Thus it is evident that the consumption of squalene supplements can help to prevent the occurrence of breast cancer.
Varicose vein is the condition, in which the veins become enlarged, gnarled and overfilled with blood. Varicose veins have bluish-purple or red colour and they appear as swollen and raised. They are usually painful. Any vein can become varicose, however, the veins of legs and feet most commonly get affected because standing and walking upright elevates the pressure in the veins of the lower body.
The risk of varicose vein is higher in aged people, females, obese people and who carry the family history of varicose vein. Moreover standing or sitting for long periods of time can also increase the risk of varicose vein.
Many studies have found that the women are more prone to develop varicose veins than men. It may be due to the hormone progesterone, which is produced by both men and women, but levels are much higher in women. Therefore, scientists believe that the progesterone is at least one of the reasons behind the susceptibility of women to develop varicose vein more. Along with regulation of menstrual cycles and the maintenance of many organs, the progesterone hormone also causes the relaxation of blood vessel wall. Researchers believe that, with the relaxation of these walls, the tiny valves present within the vessels also relaxes and the pressure exerted by flow of blood pushes out on the sides of the vessels. This makes them weaker and increases the risk of varicose veins.
There are various treatments available for varicose vein including self-care measures. However, the best option for controlling varicose vein is the use of squalene health supplements.
Role of Squalene in Controlling the Condition of Varicose Veins
The squalene controls the varicose veins in a number of ways:
- By Improving Blood Circulation: Squalene improves the blood circulation by reducing the cholesterol in the body as it increases the high-level lipoproteins and decreases the low-level lipoproteins. Thus the levels of cholesterol in body decreases and arteries regain their size which facilitates improved blood circulation.
- By Acting as Anti-Ageing: Squalene delays ageing in a number of ways as by preventing obesity, acting as anti-oxidant and stress buster thus it controls the condition of varicose veins. Therefore, the arteries remain elastic and the blood circulation remains continuous without any backflow.
For every man, from factory workers to athletes, stamina is very important. Stamina means the capacity to carry on prolonged physical or mental effort. Well, the men who have strong immunity possess well-built stamina as the major function of the immune system is to protect our body from the microbes or chemicals. Otherwise, persistent infections and diseases can lead to the low energy level in the body and hence poor stamina. Therefore, developed functioning of the immune system is highly important to attain improved stamina.
Squalene oil contains elements that improve the immune system of the individual. According to studies, the element responsible for immune boosting is alkylglycerols, which researchers have found to fight off colds, viruses and infections. Alkylglycerols are one of the components present in squalene oil. They are found to fight cancer by killing tumour cells indirectly. They activate the immune system by:
- promoting immune system cells known as macrophages that consume attacking germs and damaged cells
- blocking inhibiting protein kinase C that acts as a key regulator of cell growth
Experimental studies reveal that squalene-supplemented diets result in an increased response of the immune system. Medical conditions, as arthritis, psoriasis and asthma may also be improved by squalene supplements. The laboratory studies confirmed that the function of macrophages is enhanced by squalene. Macrophages are the type of white blood cells which ingests bacteria and virus. Macrophages have a vital role in the functioning of the immune system of our body. They also have the ability to help wounds heal faster.
In one of the studies, researchers studied that the expecting mothers who suffer from the urinary tract infections as inflammation in the urinary tract or bladder infections have improvement in their condition with the intake of shark liver oil. Thus it is evident that growing problems with antibiotic resistance can be cleared up by using shark liver oil as an alternative solution.
Squalene contains isoprenoid structures which are known to attach cell membranes. It has significant detoxification and antioxidant capacity. Antioxidants neutralize free radicals that can result in oxidative stress. The oxidative stress can result in oxidative damage, cell death, tissue damage and disease.
Therefore, it shows that squalene has great potential as an immune-support nutrient. Thus, to attain good stamina intake of squalene is quite promising.
Nobody can change the natural aging process. With time, it’s natural to get visible lines and lose youthful fullness on face. However, premature ageing signs are never pleasing for anyone, not even for men. There are number of causes behind the early ageing in men. However, sun damage, unhealthy lifestyle and medical conditions are the common ones.
Fortunately, men can prevent the risk of early ageing by using squalene as a health supplement. Squalene is found to be an excellent anti-aging substance due to its number of effects. It has a number of properties that are beneficial in keeping skin healthy and young. It helps a person to deal with pollution, ultraviolet rays and various health conditions that can cause premature aging. Its antioxidants properties play a vital role in performing all such functions. It is stable to attack free radicals. Increased formation of free radicals results in oxidative stress that causes imbalance and leads to oxidative damage, cell death, tissue damage and disease. Squalene reduces the oxidative stress and protects the skin against lipid peroxidation as a free oxygen scavenger.
There are some of the major benefits of squalene that makes it a best anti-ageing substance:
- Squalene regenerates skin growth thus the skin remains healthy and smooth free from wrinkles and age spots.
- Squalene interrupts free radicals and inhibits them from entering the body by protecting skin from environmental triggers that cause premature ageing.
- Squalene enhances the moisture balance and elasticity to maintain the youngness of skin.
- Squalene keeps you away from the conditions like acne, allergies, eczema, scars and psoriasis, which can contribute to premature ageing.
- Squalene promotes improved blood circulation which helps to rejuvenate skin tone.
- Squalene prevents the condition of obesity by acting as a fat regulator and reducing cholesterol levels. Thus by preventing obesity, it delays ageing because according to a study obesity accelerates the ageing process more than smoking.
- Squalene acts as a stress buster thus it prevents premature ageing as stress is one of the major causes of early ageing.
Thus, the people who use squalene supplements are able to keep their skin young and flawless without any fine lines or wrinkles.
Loss of libido is a common problem which affects up to one in five men at some point in their life. It is usually associated with personal and professional stress. But, an unexpected loss of libido particularly when it occurs continuously can be the sign of an underlying personal, lifestyle or medical problem that can be distressing to both partners in a relationship.
Testosterone hormone is most closely linked with male sex drive. It is a hormone which is produced mainly in the testicles. Low levels of testosterone usually cause low libido. Many men with low testosterone opt for testosterone therapy to improve their libido. However, it has a number of side effects as:
- Acne or oily skin
- Stimulation of prostate tissue, with possibly some increased urination symptoms
- Elevated risk of developing prostate abnormalities
- Increased risk of blood clots
- Worsening of sleep apnea
- Decreased testicular size
- Increased aggression and mood swings
- increased risk of heart attack
According to a number of studies, testosterone therapy can elevate the risk of a heart attack. This is one of the most serious risks of testosterone therapy. Men under 65 years of age with pre-existing heart disease are at greater risk of having a heart attack soon after starting testosterone therapy.
Thus it is better to choose something of natural origin to enhance your libido so as to avoid any side effects. Squalene is such a substance that is known to enhance libido or sexual vitality without causing any side effects as it has a natural origin. Various researchers show that Squalene helps in the formation of adrenal hormones as well as sex hormones for males including testosterone, androgens, vitamin D and other sex hormones. Therefore intake of squalene improves sexual vitality.
Moreover, the cellular activities in the scrotum are high thus nutrients and oxygen are constantly required in large quantities. The oxygen-supplying action of squalene enhances cellular activity in these organs; therefore the sexual vitality increases as the oxygen-rich cells ensure an efficient working of the body.
Hence it is evident that the use of squalene can help you to enhance your libido without suffering from any side effects as the other treatments for libido enhancement can cause.
Cancer is the result of cells which grow uncontrollably and do not die. Normal cells in the body grow, divide and die in an orderly path. This type of programmed cell death is known as apoptosis. When this path is broken down, cancer begins to form. The cancer cells do not undergo programmatic death and instead, they continue to grow and divide. This results in a mass of abnormal cells which grows out of control.
According to the American Cancer Society, Cancer is the second commonest cause of death in the US and it accounts for around 1 of every 4 deaths. It is a major cause of death worldwide. Deaths from cancer worldwide are rising continuously and estimated to be 13.1 million deaths in 2030.
Cancer researchers observed that there is a correlation between a high amount of squalene in shark and the absence of cancer in this species. The mechanism behind the action of squalene in preventing cancer is its ability to decrease mutated ras oncogene activation. Ras oncogene is a family of genes that produce proteins linked to the cell signalling pathways which manage cell growth and cell death. Studies have shown that squalene acts as an anti-cancer agent by decreasing farnesyl pyrophosphate (FPP) levels in cells as the prenylation of FPP is needed for oncogene activation.
Moreover, squalene is an excellent free radicals scavenger; therefore, it protects cells and organs from auto-oxidative damages. Squalene has antioxidant properties; therefore, it neutralizes the free radicals. The increased generation of free radicals can result in oxidative stress that can produce imbalance leading to oxidative damage, cell death, tissue damage and ultimately a medical condition.
It is better to prevent the occurrence of such a lethal disease rather than opting for unreliable treatments once such a disease attacks. Squalene being a product of natural resource does not cause any side effect. Its daily intake as a health supplement can reduce the risk of developing various types of cancers.
It is normal for children to have infections caused by microorganisms such as bacteria, fungi or viruses. However, there reoccurrence is not normal. Reoccurring infections are the indications that there is problem of immune system in your child.
A child will suffer from a number of infections and life-threatening conditions if he or she does not possess a well-developed and maintained the immune system. Therefore, developed functioning of the immune system is highly important.
Squalene oil contains elements that improve the immune system of the individual. According to world health organization, Squalene has been used in certain flu vaccines. Every dose of Chriron flu and FLUAD vaccines contained nearly 10 mg of Squalene. Squalene is associated to improve immune response when used in some vaccines. According to studies, the element responsible for immune boosting is alkylglycerols, which researchers have found to fight off colds, viruses and infections. Alkylglycerols are one of the components present in Squalene oil. They are found to fight cancer by killing tumour cells indirectly. They activate the immune system by:
- promoting immune system cells known as macrophages that consume attacking germs and damaged cells
- blocking inhibiting protein kinase C that acts as a key regulator of cell growth
Alkylglycerols also decrease the adverse effects of chemotherapy and radiation treatment due to their ability to protect cell membranes.
Experimental studies reveal that Squalene-supplemented diets result in an increased response of the immune system. Medical conditions, as arthritis, psoriasis and asthma may also be improved by Squalene supplements. The laboratory studies confirmed that the function of macrophages is enhanced by Squalene. Macrophages are the type of white blood cells which ingests bacteria and virus. Macrophages have a vital role in the functioning of the immune system of our body. They also have the ability to help wounds heal faster.
In one of the studies, researchers studied that the expecting mothers who suffer from the urinary tract infections as inflammation in the urinary tract or bladder infections have improvement in their condition with the intake of shark liver oil. Thus it is evident that growing problems with antibiotic resistance can be cleared up by using shark liver oil as an alternative solution.
Squalene contains isoprenoid structures which are known to attach cell membranes. It has significant detoxification and antioxidant capacity. Antioxidants neutralize free radicals that can result in oxidative stress. The oxidative stress can result in oxidative damage, cell death, tissue damage and disease.
Therefore, it shows that Squalene has great potential as an immune-support nutrient. Thus for the maintenance of good immune response, intake of Squalene is quite promising.
Infection is the invasion and multiplication of microbes as viruses, bacteria and parasites which are not usually present in the body. An infection can remain localized, or it can spread throughout the body through lymphatic vessels or the blood.
Children develop infections more frequently as compared to adults due to number of causes. It is found that the young children in child care centers are more susceptible to have infections as they have not developed the required protective immunities. Moreover, many children at pre-school age have not yet learned to properly wash their hands and thus germs from the hands of an infected child may get transmitted to others through sharing of toys or touching each other.
Well, it is the matter of concern if your child suffers from infections frequently as some diseases or medicines weaken the immune system. Therefore, if medicines lower the immune system, then it is better to choose an alternative treatment as health supplements. There are certain health supplements that can be considered for protecting your child against infections.
Squalene is known to be excellent health supplement for protecting against infections due to a number of benefits. Squalene has numerous health benefits. Protection against flu and infections is one of those benefits. Squalene has certain elements which improve the immunity of a person. According to the American Cancer Society, Squalene contains alkylglycerols that can defend against colds, viruses and other infections.
Alkylglycerols stimulate the immune system and give protection against uncontrolled, malignant cell growth. According to Swedish biochemist Sven Brohult, alkylglycerols aid the production of white corpuscles that are responsible for the optimal functioning of immune system. Alkylglycerols are also present in the body organs that are essential for immune defense as lymph nodes, spleen as well as in bone marrow and milk of the mother. Shark liver oil contains much more of it. Moreover, the macrophages present in Squalene have the ability to aid the healing of wounds.
Hence, the role of Squalene in protecting against infections and enhancing immunity is manifested.
Children are more vulnerable to the adverse effects of air pollution than are adults. Children have increased exposure to many air pollutants compared with adults because children spend more time outdoors than adults, thus they have increased exposure to outdoor air pollution.
There are numerous toxins floating in the air we breathe, which are regularly being produced by motor vehicles, industrial facilities, residential wood combustion, agricultural burning, and many other sources. The levels tend to be highest on warm, sunny, windless days and often peak in mid-afternoon when children are most likely to be playing outside.
Effects of Pollution on the Skin of children:
- Ozone in photochemical smog diminishes Vitamin E levels in the skin, disturbing wound-healing processes and stimulating oxidative stress.
- Skin exposed to pollution suffers a higher sebum secretion rate as compared to non-polluted areas.
- Cutaneous pH tends to reduce when exposed to pollution.
- Squalene and vitamin E are the main antioxidants at the skin surface. Squalene is reduced in polluted areas because it is mobilized to fight oxidative stress in the skin.
Human skin faces an aerial oxidative environment naturally. The environment presents an unpredictable oxidative potential because it is enhanced by solar rays probably combined with aerial-borne pollutants which most commonly act as catalysts in the diverse oxidative pathways. The human sebum highly present on the upper parts of the body as the face is thus a natural “receptor” of these oxidative actions. 10–20 % of sebum is Squalene which is highly sensitive towards different types of Reactive Oxygen Species. Squalene appears as natural bio-markers of most oxidative reactions on the cutaneous tissue.
Squalene being an antioxidant can act as oxygen supplement. It is highly sensitive to singlet oxygen which is a very reactive oxidative species. It assists the oxygen delivery throughout the body. The antioxidants neutralize free radicals. Increased production of free radicals can result in oxidative stress, causing imbalance and leading to oxidative damage, cell death, tissue damage and finally disease. Inhalation of cigarette smoke and exposure to air pollution contribute a lot to the generation of free radicals.
The intake of squalene as a health care supplement is crucial to deal with the pollution as the levels of squalene gets decreased due to pollution. Squalene can help a lot to deal with pollution by neutralizing the increased production of free radicals. Thus a number of medical conditions in children can be prevented by using squalene as a health supplement, which can occur due to increased free radicals.
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