The term â€˜inflammatory bowel disease (IBD) refers to two chronic diseases that cause inflammation of the bowels or intestines: ulcerative colitis and Crohnâ€™s disease. Omega-3 fatty acids have the most potent immunomodulatory activities, and among the omega-3 PUFA, those from fish oil (EPA and DHA) are more biologically potent than ALA. Hence, these fatty acids may inhibit an increase of proinflammatory markers. When added to standard medication, such as sulfasalazine, omega-3 fatty acids may reduce symptoms of Crohnâ€™s disease and ulcerative colitis. In children with Crohnâ€™s disease, omega-3 FAs (EPA and DHA) together with mesalazine treatment (5-ASA) effectively maintained disease remission. Children who were given omega-3 fatty acids also suffered fewer relapses.