Menstrual pain or dysmenorrhea is the most common gynecologic complaint and the leading cause of short-term absenteeism among adolescent schoolgirls. In a clinical study of nearly 200 Danish women aged between 20 and 45 years, a strong association was observed between increased menstrual pain and a low intake of omega-3 fatty acids from fish.

In a study, adolescents suffered less menstrual pain while taking fish oil supplementation; the amount of painkillers taken during the menstrual periods also declined by more than 50%.